Do Antihistamines Cause Weight Gain

Do Antihistamines Cause Weight Gain

Do antihistamines cause weight gain? Antihistamines are commonly used medications that relieve allergies and various allergic reactions. However, concerns about their potential to cause weight gain have been debated and speculated.

This blog post will explore the relationship between antihistamines and weight gain, examine the scientific evidence, and offer practical tips to mitigate possible adverse effects.

Do Antihistamines Cause Weight Gain 

Antihistamines are medicationals that block the action of histamines in the body. Histamines are:

  • Chemicals released during an allergic reaction.
  • Leading to symptoms such as sneezing.
  • Itching.
  • Runny nose.

Antihistamines work by inhibiting histamine receptors, effectively reducing these symptoms and relieving allergy sufferers.

Clarifying the Myth: Antihistamines and Weight Gain

Contrary to popular belief, limited scientific evidence supports the claim that antihistamines directly cause weight gain. Most over-the-counter and prescription antihistamines do not contain properties that alter metabolism or significantly affect energy balance.

However, it is crucial to note that some individuals may experience an increase in appetite while taking antihistamines. This potential side effect could lead to weight gain indirectly if the individual consumes more calories than their body requires. However, the increase in appetite is not caused by the antihistamine itself but rather by individual differences in how people respond to medication.

Some older, first-generation antihistamines (such as diphenhydramine) may have sedative effects that can cause drowsiness. As a result, individuals may feel less motivated to engage in physical activities, which can indirectly contribute to weight gain over time.

Do Antihistamines Cause Weight Gain

Common Antihistamines on the Market:

There are principal forms of antihistamines: first-era and 2nd-era. Diphenhydramine and chlorpheniramine, which belong to the first-generation antihistamines, have been used for decades. Second-generation antihistamines, like loratadine, cetirizine, and fexofenadine, are newer and often preferred due to their reduced sedative effects.

The Myth of Antihistamines and Weight Gain:

The idea that antihistamines cause weight gain has been widely circulated, but it is essential to separate fact from fiction. There is limited scientific evidence to directly support the claim that antihistamines cause weight gain in individuals. The misconception likely stems from the fact that some first-generation antihistamines, which are rarely prescribed today, can cause increased appetite and water retention, leading to temporary weight gain in some users.

Second-generation antihistamines, the ones more commonly used today, have been extensively studied, and no concrete evidence links them to significant weight gain. However, individual responses to medications can vary, and some people might experience slight changes in appetite or other factors that could indirectly influence their weight.

Factors that Might Influence Weight while Taking Antihistamines:

While antihistamines themselves may not directly cause weight gain, several factors can influence an individual’s weight during their use:

  1. Increased Appetite: Some individuals may experience increased appetite while taking certain antihistamines. However, this effect is generally mild and may not significantly impact weight if dietary choices remain balanced.
  2. Sedation: First-generation antihistamines can cause drowsiness in some individuals, reducing physical activity and potential weight gain. Second-generation antihistamines have minimal sedative effects, mitigating this concern.
  3. Water Retention: In rare cases, certain antihistamines may cause mild water retention, resulting in temporary weight gain. However, this usually resolves when the medication is discontinued.

Tips to Manage Potential Weight Effects:

If you are concerned about potential weight changes while taking antihistamines, here are some practical tips to help manage any effects

  1. Opt for Second-Generation Antihistamines: Whenever possible, choose second-generation antihistamines, as they are less likely to cause drowsiness or appetite changes.
  2. Monitor Your Diet: Be mindful of your dietary choices and portion sizes to prevent any minor increases in appetite from leading to weight gain.
  3. Stay Active: Regular physical activity can counteract sedative effects and contribute to weight management.
  4.  Drinking too much water can help mitigate temporary water retention effects.

Choosing the Right Antihistamine:

If the possibility of weight gain worries you while utilizing while using antihistamines.

They can recommend alternative antihistamines with fewer sedative effects or suggest other strategies to manage allergy symptoms effectively.

Do Antihistamines Cause Weight Gain

 Maintaining a Healthy Lifestyle:

Whether you take antihistamines or not, maintaining a healthy lifestyle is key to managing your weight effectively. Here are some suggestions to keep in thoughts:

Balanced Diet: Focus on ingesting a variety of nutrient-dense foods inclusive of culmination, veggies, entire grains, lean proteins, and wholesome fat. Be aware of component sizes and avoid excessive consumption of processed meals and sugary drinks.

  1. Regular Physical Activity: Engage in exercise or physical activities you enjoy. This can include on foot, running, biking, swimming, or another shape of cardio exercise. Aim for at least hundred and 150 minutes of mild-intensity exercise or 75 minutes of lively-intensity exercise in line with the week. Stay Hydrated: Drink a good enough amount of water all through the day to assist ordinary health and maintain proper hydration.
  2. Stress Management: Find healthy ways to manage stress, such as practicing mindfulness, engaging in hobbies, or seeking support from friends, family, or professionals.


In conclusion, the claim that antihistamines cause significant weight gain lacks substantial scientific evidence, especially concerning the second-generation antihistamines commonly prescribed today. While individual responses to medications can vary, the potential for weight gain is minor and manageable for most users.

As always, discussing any concerns with your healthcare provider to determine the most appropriate treatment approach for your allergies while considering your overall health and well-being is essential.

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